現(xiàn)貨moradec AM-107-DX說明書

αMFc-CL-DX8951

具有可切割連接子的抗小鼠IgG Fc-DX8951抗體

目錄號：AM-107-DX

αMFc-CL-DX9851是一種抗小鼠IgG Fc特異性抗體，與甲磺酸埃克替康（DX8951）結(jié)合。抗體部分是對小鼠IgG的Fc區(qū)特異的多克隆抗體。甲磺酸埃克替康（DX8951）是一種拓?fù)洚悩?gòu)酶I抑制劑。連接DX8951和抗體的可裂解接頭（GGFG）在細(xì)胞外液中是穩(wěn)定的，但一旦綴合物通過內(nèi)吞作用進(jìn)入細(xì)胞，則在內(nèi)體中被裂解。

αMFc-CL-DX8951

Anti-Mouse IgG Fc-DX8951 Antibody with Cleavable Linker	Catalog Number: AM-107-DX
αMFc-CL-DX9851 is anti-mouse IgG Fc specific antibody conjugated to exatecan mesylate (DX8951) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of mouse IgGs. Exatecan mesylate (DX8951) is a topoisomerase I inhibitor. The cleavable linker (GGFG) connecting DX8951 to the antibody is stable in extracellular fluid, but is cleaved by in endosome once the conjugate has entered a cell via endocytosis.